Collaborative research with the department of biochemistry at University of Leicester
NUR4022: Introduction to nursing practice & decision making-physiology;
NUR4024: Adult nursing practice1;
NUR 5066: Adult nursing practice 2,
NUR4023: Heath in Society: LBR 6364: applied pharmacology for health and social care; Adult critical care and cardiac pathway for dimension Healthcare framework.
Angiopoietin-1 is an important growth factor involved in maintaining normal vascular stability and integrity by endothelial transduction. Harprit's research continues to expand knowledge in the field of Angiopoietin-1 signalling and the relevance it may have with pathogenesis of cardiovascular disease.
Singh, H., and Brindle. N. (2012). Angiopoietin 1 signalling, a marker of endothelial dysfunction in patients with coronary artery disease. From the 4th BPS Focused Meeting on Cell Signalling, Leicester, Spring 2012: Proceedings of the British Pharmacological Society.
Singh, H., Hansen, T., Patel, N., and Brindle, N.PJ. (2012) The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNF and regulates Angiopoietin signalling. PLoS ONE, 7 (1) doi: 10.1371/journal.pone.0029319
Singh, H., Brindle, N.P.J, and Zammit, V.A. (2010) High glucose and elevated fatty acids suppress signalling by the endothelium protective ligand Angiopoietin-1. Microvascular Research, 9 (2) 121-127
Hansen, T.M., Singh, H., Tahir, T.A. and Brindle, N.P.J (2010) Effects of angiopoietins-1 and-2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface. Cellular Signalling, 22 (3) 527-532
Singh, H., Milner, C.S., Aguilar Hernandez, M.M, Patel, N., Brindle, N.P.J (2009) Vascular endothelial growth factor activates the Tie family of receptor tyrosine kinases. Cellular signalling, 21 (8) 1346-1350
Milner, C.S., Hansen, T.M., Singh, H., and Brindle, N.P.J (2009) Roles of the receptor tyrosine kinase Tie1 and Tie2 in mediating the effects of angiopoietin-1 on endothelial permeability and apoptosis. Microvascular Research, 77: 187-191.
Rees, K.A., Singh, H., and Brindle, N.P.J. (2007) The receptor tyrosine kinase Tie1 is expressed and activated in epithelial tumour cell lines. International Journal of Oncology, 31: 893-897.
Marron, M.B., Singh, H., Tahir, T.A., Kavumkal, J., Kim, H., Koh, G.Y., and Brindle, N.P.J (2007) Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor tyrosine kinase Tie2. Journal of Biological chemistry, 282 (42) 30509-30517.
Rainbow, R.D, James, M., Hudman, D., Al Johi, M., Singh, H., Watson, P.J., Ashmole, I., Davies, N., Lodwick, D., and Norman, R.I. (2004) Proximal C-terminal domain of sulphonylurea receptor 2A interacts with pore-forming Kir6 subunits in KATP channels. Biochem J, 379:173-81
Singh, H., Hudman, D., Lawrence, C.L., Rainbow, R.D., Lodwick, D., and Norman, R.I. (2003) Distribution of Kir6.0 and SUR2 ATP-sensitive K+ channel subunits in isolated ventricular myocytes. Journal of molecular and cellular cardiology, 35 (5) 445-459.
