Tariq Tahir

Senior Lecturer

Email:: Tariq.tahir@bcu.ac.uk
Phone:: 0121 331 7103

Tariq completed his undergraduate degree at the University of Liverpool in Microbiology. After graduation with a BSc Hons, he completed an International MSc at DeMontfort University, Leicester, where most of the learning was conducted in the Netherlands and Austria. Following the completion of his MSc, he secured a job as a research assistant at the University Hospital of Vienna, from 1997 to 2000, studying apoptotic mechanisms in lung cancer cells. Tariq presented his data at various conferences in Brussels and Rio de Janeiro.

Tariq returned to the UK to study for a PhD at the Institute of Food Research/University of East Anglia from 2001 to 2004. His PhD was focused on developing enzymes through in-vitro mutagenesis and heterologous expression in Yeast. The PhD project was funded by the European Commission and BBSRC and was in partnership with several European institutes. Tariq enjoyed success in his PhD by presenting data at various conferences in Europe.

From 2004 to 2015, Tariq was employed as a senior postdoctoral scientist at the University of Leicester in the Biochemistry lab of Professor Nicholas Brindle, where he worked on many BHF funded grants looking at the molecular interactions of the Tie2/Tie1/Ang1 axis, which is crucial for protection against noxious stimuli in Blood vessel endothelial cells, protecting underlying tissue such as cardiac tissue.

Having spent 11 years as postdoctoral scientist, Tariq changed his career to teaching and secured a lectureship position at BCU in 2015 and continues to this day.

Areas of Expertise

Qualifications

Teaching

Research

Publications

Alawo DOA, Tahir TA, Fischer M, Bates DG, Amirova SR, Brindle NPJ. Regulation of Angiopoietin Signalling by Soluble Tie2 Ectodomain and Engineered Ligand Trap. Scientific Reports. (2017); 7, 3658.
Tahir TA, Singh H, Brindle NP. hnRNPK mediates ligand-induced translational control of uncoupling protein-2. (2014). Cell. Signal. 26, 1379-84
Singh H, Tahir TA, Alawo DO, Issa E, Brindle NP. Molecular control of angiopoietin signaling. (2011), Biochem. Soc. Trans. 39, 1592-6.
Hansen TM, Singh H, Tahir TA, Brindle NP. Effects of angiopoietin -1 and -2 on the receptor tyrosine kinase Tie2 are differently regulated at the endothelial cell surface. (2010), Cell Signal. 22, 527-32.
Marron MB, Singh H, Tahir TA, Kavumkal J, Kim HZ, Koh GY, Brindle,. Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2. (2007), J. Biol. Chem., 282, 30509-17.
Xavier Rouau, Stéphanie Daviet, Tariq Tahir, Benjamin Cherel, Luc Saulnier. Effect of the proteinaceous wheat xylanase inhibitor, XIP-1 on the performances of an Aspergillus niger xylanase in breadmaking (2006) Journal of the Science of Food and Agriculture, 86, 1604-1609.
Tahir TA, Durand A, Gebruers K, Roussel A, Williamson G, Juge N. Functional importance of Asp37 from a family 11 xylanase in the binding to two proteinaceous xylanase inhibitors from wheat. (2004) FEMS Microbiol. Lett., 239, 9-15
Sorensen JF, Kragh KM, Sibbesen O, Delcour J, Goesaert H, Svensson B, Tahir TA, Brufau J, Perez-Vendrell AM, Bellincampi D, D'Ovidio R, Camardella L, Giovane A, Bonnin E, Juge N. Potential role of glycosidase inhibitors in industrial biotechnological applications. (2004) Biochim Biophys Acta. 1696, 275-287.
Brutus A, Villard C, Durand A, Tahir T, Furniss C, Puigserver A, Juge N, Giardina T. The inhibition specificity of recombinant Penicillium funiculosum xylanase B towards wheat proteinaceous inhibitors. (2004) Biochim Biophys Acta. 1701-121-128.
Payan F, Leone P, Porciero S, Furniss C, Tahir T, Williamson G, Durand A, Manzanares P, Gilbert HJ, Juge N, Roussel A. The dual nature of the wheat xylanase protein inhibitor XIP-I: structural basis for the inhibition of family 10 and family 11 xylanases. (2004) J. Biol. Chem. 279, 36029-36037.
Tahir, T. A., Berrin, J. G., Flatman, R., Roussel, A., Roepstorff, P., Williamson, G., and Juge, N. Specific characterization of substrate and inhibitor binding sites of a glycosyl hydrolase family 11 xylanase from Aspergillus niger. (2002) J Biol.Chem. 277, 44035-44043.
Caputi, M., Groeger, A. M., Esposito, V., De Luca, A., Murabito, M., Tahir, T., Giordano,G. G., Baldi, F., Giordano, A., and Wolner, E. Frequent high expression of bax pro-apoptotic protein in non-small cell lung cancer. (1999) Anticancer Res. 19, 825-827.

Poster Presentations

Singh, H., Hansen, T.M., Patel, N., Tahir, T.A. and Brindle, N.P.J. (2011) The molecular balance between receptor tyrosine kinases TIE1 and TIE2 is dynamically controlled by diverse agonists and regulates responsiveness of TIE2 to its ligand. In: Signalling 2011: Biochemical Society Centenary Conference, University of Edinburgh. P010
C.S. Milner, H. Singh, T.A. Tahir and N.P.J Brindle. Role of Tie2 in suppression of endothelial permeability by Angiopoietin-1.4th European Meeting on Vascular Biology and Medicine 2007.
Tariq A. Tahir, Jean Guy Berrin, Ruth Flatman, Gary Williamson and Nathalie Juge. Characterisation of a family 11 xylanase-binding site with the wheat proteinaceous inhibitor, XIP-I. 3rd European Symposium on Enzymes in Grain Processing, Leuven, Belgium, 25-27 September 2002 (Awarded 2nd prize for best posters).
Tariq A. Tahir, Jean Guy Berrin, Ruth Flatman, Gary Williamson and Nathalie Juge Characterisation of a family 11 xylanase-binding site with the wheat proteinaceous inhibitor, XIP-I. EU Framework V Gemini Workshop, Marseille, France, 13-15 June 2002.
Tariq A. Tahir, Ruth Flatman, Jean Guy Berrin, Russell McLauchlan, Gary Williamson and Nathalie Juge. Interactions defining the specificity of A. niger xylanase to the wheat Proteinaceous inhibitor XIP-I as dissected by mutational analysis. 4th Carbohydrate Bioengineering Meeting, Stockholm, Sweden, 10-13 June 2001.
T.A. Tahir, A. Groeger, K. Marcfelda, T. Wild, E. Wolner and M.R. Mueller. Liposome-mediated transfection of bax induces an acceleration of apoptosis in a lung cancer cell line. The 12th Annual meeting of the European Association for Cardiothoracic Surgery, Brussels, Belgium, 1998.
Tahir, T. A., Groeger, A. M., Esposito, V.,Baldi, F., Giordano, A., Mueller, M. R. and Wolner, E. Differential expression of apoptosis-related proteins in lung cancer. The 17th International Cancer Congress, Rio de Janeiro, Brazil, 1998.