Dr Martin Figgitt

Lecturer in Biomedical Sciences

School of Health Sciences

Email:: Martin.figgitt@bcu.ac.uk

Martin has a very strong and varied biomedical science background having been engaged in both research activities and clinical diagnostic services.

His clinical science experience includes working in hospital blood sciences laboratories performing various blood tests, such as full blood counts, coagulation screening and blood film analysis and blood transfusion serology and cross matching. Other clinical experience involved working clinical genetics centres, performing a range of genetic tests such as cytogenetics, molecular cytogenetics and DNA sequencing, on pre-natal, post-natal and cancer tissue samples.

His research activities have been in the areas of genomic instability in particular in relation to radiation exposure, nanoparticle toxicology and ageing. These have been undertaken in various research establishments in the UK such the Medical Research Council, Harwell, Oxon, and the School of Clinical Sciences, University of Bristol.

Other research activities have included creating three-dimensional collagen scaffolds to be used in producing laboratory skin ageing models. Together with blood vessel and connective tissue collagen scaffolds as possible surgical augmentation devices.

Areas of Expertise

Qualifications

Memberships

Teaching

Research

Postgraduate Supervision

Publications

Figgitt M (2021). Skin Ageing: The need for skin ageing models for healthy ageing. Journal of the Institute of Ageing and Health. 22

Mehta IS., Riyahi K, Pereira RT, Meaburn KJ, Figgitt M., Kill IA., Eskiw CH, Bridger JM (2021). Interphase chromosomes in replicative senescence: chromosome positions as a senescence biomarker and the lack of nuclear motor-driven chromosome repositioning in senescent cells. Front Cell dev Biol 9 593

A study of metal levels and chromosome aberrations in the peripheral blood, urine and buccal mucosa of patients with metal on metal hip resurfacing arthroplasty. M.Figgitt, AD Maclean, M Parry, R Newson, D Gillett, K Denton, GC Bannister, I Learmonth, S Eastaugh-Waring, AW Blom, CP Case. Lancet on prep (IF 34.2)

The cytogenetic effects of orthopaedic wear debris upon cultured fibroblasts. M.Figgitt, R Newson. I Leslie, I Ingham, J Fisher, CP Case. Biomaterials in prep (IF 7.4)

The genotoxicity of physiological concentrations of chromium (Cr(III) and Cr(VI)) and cobalt
(cobalt (Co(II)): An in vitro study. Martin Figgitt, Roger Newson, et al. Mutat Res. 688 (2010) 53-61 (IF 2.8)

Alterations to nuclear architecture and genome behaviour in senescent cells. Mehta IS, Figgitt M, Clements CS, Kill IR, Bridger JM. Ann N Y Acad Sci. 2007. 1100:250-63

Collaborative exercise on the use of FISH chromosome painting for retrospective biodosimetry of Myak nuclear-industrial personnel. Bauchinger M, Figgitt M, et al. Int, J, Radiat, Biol, 200177,259-67

Constructing a 2B calibration curve for retrospective dose-reconstruction. Savage JRK, Papworth DG, Bauchinger M, Figgitt M, et al. Radiation Protection Dosimetry. 2000.88, 1, 69076

Interphase Chromosome Domain Reorganisation Following Irradiation. Figgitt M, Savage J.
Int, J, Radiat, Biol. 1999. 75,811-17

Radiation Fields, Dosimetry, Biokinetics and physical models for cancer by ionising radiation 1996-1999. Part4. Dose reconstruction. Jacob P, Bauchinger M, Figgitt M, et al. GSF-Ber. 130-161

Conference Papers:

The Versatile Application of Cultured Insect Cells, in Cell Biology, Research and Higher Education Cell Biology Teaching. Martin Figgitt. BSCB/BSDB/Genetics combined Spring Conference April 2017

Genotoxicity Of Orthopaedic Wear Debris: A Patient Study. Martin Figgitt. Michael Parry, Angus Maclean, Ashley Blom, Gordon Bannister, Steve Eastaugh-Waring, Ian Learmonth, Wilson Li, Charles Case. British Toxicology Society Annual Congress March 2011

Genomic Instability Induced by orthopaedic Wear Debris In Cultured Human Fibroblasts. Martin Figgitt Roger Newson, Ian Leslie, John Fisher, Eileen Ingham, Charles Case, British Toxicology Society Annual Congress March 2011

Genotoxic effects of Orthopaedic wear debris on the bladder? AD MacLean, CP Case M Figgitt, W Li. British Journal of Medical and Surgical Urology. Vol 3, Issue 6 p263-64 (Nov 2010)

The use of M-FISH to investigate genome instability in cells exposed to orthopaedic implant wear debris. . M.Figgitt and CP Case. Presentation: Association for clinical Cytogenetics (ACC), Spring Conference (April 2008)

3D collagen matrices: Applications in treatments of aged-related diseases and in ageing studies. Martin Figgitt, Sunil Pancholi, Ian kill. Poster presentation 5th European Congress of Biogerontology, Istanbul, Turkey (Sept 2006). Awarded Certificate of appreciation for novelty, relevance and presentation