Dr David Charles Hughes

Associate Professor in Life Sciences

School of Health Sciences

Email:: david.hughes@bcu.ac.uk
Phone:: 0121 331 7179

David has the following qualifications: BSc Biochemistry (UMIST), PhD Cancer Research (University of Surrey/Marie Curie Research Institute/UWCM, Cardiff).

David has 18 years of teaching experience at University of Birmingham, University of Derby and Nottingham Trent University. He has taught at foundation, level 4-6 undergraduate and also at masters level.

He has a research career of over 30 years in MRC units and UK Universities, with research experience in cancer research, developmental genetics, genetics of deafness, reproductive biology and comparative analysis.

David's current research areas include molecular exaptation of SINEs in mammalian genes, identification of antimicrobial peptides in reptiles, evolution of vertebrate egg envelope genes, and genetics of stress fracture susceptibility in elite athletes.

Areas of Expertise

Qualifications

Memberships

Teaching

Research

Postgraduate Supervision

Publications

Varley, I., Hughes, D.C., Greeves, J. Fraser, W. & Sale, C. Increased training volume improves bone density and cortical area in adolescent footballers. International Journal of Sports Medicine (2017) Accepted for publication
Pitsiladis YP, Tanaka M, Eynon N, Bouchard C, North KN, Williams AG, Collins M, Moran CN, Britton SL, Fuku N, Ashley EA, Klissouras V, Lucia A, Ahmetov II, de Geus E, Alsayrafi M; Athlome Project Consortium.. Athlome Project Consortium: a concerted effort to discover genomic and other "omic" markers of athletic performance. Physiol Genomics. (2016) 48:183-90
Varley I, Greeves JP, Sale C, Friedman E, Moran DS, Yanovich R, Wilson PJ, Gartland A, Hughes DC, Stellingwerff T, Ranson C, Fraser WD, Gallagher JA. Functional polymorphisms in the P2X7 receptor gene are associated with stress fracture injury. Purinergic Signal. (2016) 12:103-13
Varley I, Hughes DC, Greeves JP, Stellingwerff T, Ranson C, Fraser WD, Sale CRANK/RANKL/OPG pathway: genetic associations with stress fracture period prevalence in elite athletes.Bone. (2015) 71:131-6
Laversin SA, Phatak VM, Powe DG, Li G, Miles AK, Hughes DC, Ball GR, Ellis IO,Gritzapis AD, Missitzis I, McArdle SE, Rees RC. Identification of novel breast cancer-associated transcripts by UniGene database mining and gene expression analysis in normal and malignant cells. Genes Chromosomes Cancer. (2013) 52:316-29.
Phatak VM, Croft SM, Rameshaiah Setty SG, Scarpellini A, Hughes DC, Rees R, McArdle S, Verderio EA. Expression of transglutaminase-2 isoforms in normal human tissues and cancer cell lines: dysregulation of alternative splicing in cancer. Amino Acids. (2013) 44:33-44.
Newton, M.I. Atherton, S., Morris, R.H., Stanley, S.M., Evans, C.R., Hughes, D.C., McHale, G. Low-Cost QCM Sensor System for Screening Semen Samples Journal of Sensors, Volume 2010 (2010), Article ID 326365 doi:10.1155/2010/326365
Atherton, S., Evans, C.R., Roach, P., Hughes, D.C., McHale, G., Newton, M.I. Investigation of operating parameters for a semen quality analysis system Biodevices (2009): Proceedings of the international conference on biomedical electronics and devices 13-16
Hughes, D.C. ZP genes in Avian species indicate the dynamic evolution of the Vertebrate Egg Envelope. (2007) Cytogen. Gen. Res. (Avian Genomics Special Issue) 117:86-91
Conner, S.J., Lefievre, L., Hughes, D.C., & Barratt, C.L. (2005) Cracking the egg: increasing complexity in the zona pellucida. Hum. Reprod. 20: 1148-1152
Smith, J., Paton, I.R., Hughes, D.C. and Burt, D.W. (2005) Isolation and Mapping the Chicken Zona Pellucida Genes: An Insight into the Evolution of Orthologous Genes in Different Species. Mol. Reprod. Dev. – 70:133-145.
Dove, S.K., McEwen, R.K., Yu, J.W., King, M.C., Hughes, D.C., Thuring, J., Holmes, A.B., Cooke, F.T., Michell, R.H., Parker, P.J. and Lemmon, M.A. (2004) A family of protein targets for phosphatidylinositol 3,5-bisphosphate –EMBO J 23:1922-1933
Lefievre, L., Conner, S.J., Salpekar, A., Olufowobi, O., Ashton, P., Pavlovic, B., Lenton, W., Afnan, M., Brewis, I.A., Monk, M., Hughes, D.C. and Barratt, C.L. (2004) Four zona pellucida glycoproteins are expressed in the human. Hum Reprod. 19: 1580-1586
Kilani, Z., Ismail, R., Ghunaim, S., Mohamed, H., Hughes, D., Brewis, I.A. and Barratt, C.L.R. (2004) A study and treatment of five brothers with complete globozoospermia Fertility & Sterility 82:1436-1439
Conner, S.J. and Hughes, D.C.(2003) Analysis of teleost fish egg envelope genes supports both genome duplication and species-specific amplification models Reproduction 126: 347-352
Dove, S.K., McEwen, R.K., Mayes, A., Hughes, D.C., Beggs, J.D. and Michell, R.H. (2002) Svp2 is an activator of the Fab1 PtdIns3P 5-kinase that regulates vacuole acidification and MVB sorting Current Biology 12:885-893
Barratt, C.L.R., Hughes, D.C., Afnan, M. and Brewis, I.A. (2002) Functional Genomics in Reproductive Medicine. Human Fertility, 5: 3-5
Hughes, D.C. (2001) Alternative splicing of the human VEGFR-3/FLT4 gene as a consequence an integrated human endogenous retrovirus. J. Mol. Evol. 53: 77-79
Hughes D.C. (2000) MIRs as agents of mammalian gene evolution. Trends In Genetics 16:60-2.
Paige, A.J., Kiernan, B.W., Varela, A., Rogers, M.J., Hughes, D., Steel, K.P., and Brown, S.D. (2000) A deletion on chromosome 4 cosegregates with the whirler deafness mutation: exclusion of Orm1 as a candidate. Mamm. Genome 11:51-7
Hughes D.C. and Barratt CL. (1999) Identification of the true human orthologue of the mouse Zp1 gene: evidence for greater complexity in the mammalian zona pellucida? Biochim Biophys Acta. 1447:303-306
Verhoeven, K., Van Laer,L., Kirschhofer, K., Legan, P.K., Hughes, D.C., Verstreken, M., J. Govaerts, P.J., Schatteman,I., Van Hauwe, P., Coucke, P., Chen, A., Smith, R.J.H., Van de Heyning, P., Richardson, G.P., Wachtler, F., Kimberling, W., Willems, P.J. and Van Camp, G., (1998) Mutations in human a-tectorin cause autosomal dominant non-syndromic hearing loss (DFNA12/DFNA8). Nature Genetics 19: 60-62
Taylor C., Larghero, J., Thomas, C., Warren, N., Carter, G., Hughes, D., Culligan, D., Al-Sabah, A., Whittaker, J.A., Chomienne, C. and Padua, R.A. (2000) H RAS mutations in haematologically normal individuals. The Haematology Journal1: 399-402
Hughes, D.C. Arraying bacteriophage lambda libraries for screening by PCR. Trends in Genetics, Core Protocols –Published Online 14/10/98
Hughes, D.C., Legan, P.K., Steel, K.P. and Richardson, G.P. (1998). Mapping of the alpha-tectorin gene to mouse chromosome 9 and human chromosome 11: A candidate for human autosomal dominant nonsyndromic deafness. Genomics 48: 46-51
Hughes, D.C. (1997) Paradigms and paradoxes: mouse (and human) models of genetic deafness. Audiol Neurootol 2: 3-11
Hughes, D.C., Allen, J., Morley, G., Sutherland, K., Ahmed, W., Prosser, J., Lettice, L., Allan, G., Mattei, M.G., Farrall, M. and Hill, R.E. (1997) Cloning and sequencing of the mouse Gli2 gene: localization to the Dominant hemimelia critical region. Genomics 39: 205-215
Taylor, C., Hughes, D.C., Zappone, E., Cazzola, M., Carter, G., Jacobs, A.and Padua, R.A. (1995) A screen for RAS mutations in individuals at risk of secondary leukaemia due to occupational exposure to petrochemicals. Leuk. Res. 19: 299-301
Padua, R.A., Taylor, C., Guinn, B., Baker, A., Warren, N., Bowen, D., Cachia, P., Culligan, D., Ridge, S., Carter, G., Hughes, D., White, D., Hoy, T., Burnett, A. and Jacobs, A. (1994) Genetic lesions in Preleukaemias. In: Molecular Biology of Haematopoiesis 3: 313-322
Carter, G., Hughes, D., Warren, N., Jacobs, A., Whittaker, J., Thompson, E., and Padua, R.A. RAS mutations in preleukaemia, in patients following cytotoxic therapy and in normal subjects. In: The Superfamily of ras-related genes. Ed: DA Spandidos. NATO ASI Series. Series A: Life Sciences 220:89-94, Plenum Press, New York, 1991.
Padua, R.A., Hughes, D., Nimmo, E., Schrier, P., Johnson, K. Rearrangement of the human MEL gene, the RAB 8 homologue, in human malignant melanomas. In: The Superfamily of ras-related genes. Ed: DA Spandidos. NATO ASI Series, Series A: Life Sciences 220:81-88, Plenum Press, New York, 1991.
Nimmo, E.R. Sanders, P.G, Padua, R.A., Hughes, D., Williamson, R. and Johnson, K.J. (1991) The MEL gene: a new member of the RAB/YPT class of RAS-related genes. Oncogene 6: 1347-1351
Carter, G., Hughes, D.C., Clark, R.E., McCormick, F., Jacobs, A., Whittaker, J.A. and Padua, R.A. (1990) RAS mutations in patients following cytotoxic therapy for Lymphoma. Oncogene 5: 411-416
Friel, J., Hughes, D., Nowack, A., Pragnell, I., Lohler, J., Stocking, C., Ostertag, W. and Padua, R.A. (1990) Molecular Characterisation of the Malignant Histiocytosis Sarcoma Virus LTR determines the pathogeneticity of the virus. J. Virol. 64: 369-373
Padua, R.A., Carter, G., Hughes, D., Gow, J., Farr, C., Oscier, D., McCormick, F., and Jacobs, A. RAS mutations in preleukaemias. Haematology Blut Transfusion 32: 250-254, 1989.
Jacobs, A., Padua, R.A., Carter, G., Hughes, D., Clark, R.E., Oscier, D., Bowen, D., McCormick, F. RAS mutations in primary myelodysplasia and in patients following cytotoxic therapy. In: RAS Oncogenes. Ed: D Spandidos. NATO ASI Series, Series A: Life Sciences 170:23-28, Plenum Press, New York, 1989
Padua, R.A., Carter, G., Hughes, D., Gow, J., Farr, C., Oscier, D., McCormick, F. and Jacobs, A. (1989) Ras Mutations in Preleukaemias. Modern Trends in Human Leukaemia VIII. 250-254
Shukla,V.K., Hughes, D.C., McCormick, F., Hughes, L.E. and Padua, R.A. (1989) RAS mutations in human melanocytic lesions: KRAS activation is a frequent and early event. Oncogene Res. 5: 121-127
Wright, P.A., Lemoine, N.R., Mayall, E.S., Wyllie, F.S., Hughes, D., Williams, E.D and Wynford-Thomas, D. (1989) Papillary and Follicular Thyroid Carcinomas show a different pattern of ras oncogene mutation. Br. J. Cancer 60: 576-577.
Nimmo, E., Padua, R.A., Hughes, D., Brook, D.J., Williamson, R.A. and Johnson, K.J. (1989) Confirmation and refinement of the c-MEL locus on chromosome 19 by physical and genetic mapping. Human Genetics 81: 382-384
Carter, G., Padua, R.A., Hughes, D., McCormick, F., Oscier ,D., Clark, R.E. and Jacobs, A. (1989) ras mutations in Primary Myelodysplasia and in patients following cytotoxic therapy. In: Molecular Diagnostics of Human Cancer. Cancer Cells, 7: 143-145. Cold Spring Harbor Publication
Lemoine, N., Mayall, E., Wylie, F., Farr, C., Hughes, D., Padua, R.A., Wynford-Thomas, V., Williams, E. and Wynford-Thomas, D. (1988) Activated ras oncogenes in Human Thyroid Cancers. Cancer Res. 48: 4459-4463
Gow, J., Hughes, D., Farr, C., Brown, R., McCormick, F., Oscier, D. and Padua, R.A. (1988) Activation of Ha-ras in Human Chronic Granulocytic and Chronic Myelomonocytic Leukaemia. Leukaemia Res. 12: 805-810
Padua, R.A., Carter, G., Hughes, D., Gow, J., Farr, C.J., Oscier, D., McCormick, F. and Jacobs, A. (1988) RAS mutations in Myelodysplasia detected by amplification, oligonucleotide hybridisation and transformation. Leukaemia 2: 503-510
Nimmo, E.R., Padua, R.A., Hughes, D., Williamson, R. and Johnson, K. (1987). A cDNA probe for the oncogene c-mel (pC7-1) recognises a polymorphism with NcoI. Nucl. Acids Res. 15: 3940
Spurr, N.K., Hughes, D.C., Goodfellow, P.J., Brook, D.J and Padua, R.A. (1986). Chromosomal assignment of c-mel, a human transforming oncogene to chromosome 19 (p13.2-q13.2). Somat. Cell. Mol. Genet. 12: 637-640