Martin Goldberg

• Lecturer in clinical microbiology
• Lecturer in experimental design and statistics
• Research into the development of novel antimicrobial compounds from plants and microorganisms
• On the editorial board for the International Journal of Biomedical and Clinical Analysis

• Clinical microbiology
• Bacterial molecular genetics
• Food microbiology and food safety
• Antimicrobials and resistance

• PhD
• MRSB
• FIBMS
• FHEA 

• Member of Microbiology Society
• Member of Royal Society of Biology
• Fellow of the Institute of Biomedical Sciences

BSc Biomedical Sciences

Level 4

• Introduction to Microbiology

Level 5

• Infectious Diseases (module leader)
• Research Methods (joint module leader)

Level 6

• Global control of Infectious Diseases (module leader)
• Undergrad project supervision

BSc Paramedic Science

• Infection & sepsis
• Antibiotic resistance

MSc Dietetics

• Intro to Microbiology
• Role of the human microbiome in health and disease

Martin is researching into a potent antimicrobial compound from a common plant which is showing great promise. It is toxic to all Gram positive bacteria so-far tested and includes mycobacteria. Unlike most antibiotics that take time before they start to kill the microorganisms, this compound begins to act immediately. It is rapid-acting with one strain being eliminated in 10 minutes. The compound is highly effective against multi-drug resistant pathogens such as MRSA and . Currently, Martin is exploring the development of a potential treatment for tuberculosis as many of the limited drugs available for treatment of this disease are toxic to patients, especially if infected with drug-resistant strains. Through collaborations with other institutions, we have manufactured a nanoparticle formulation of the compound which he hope can be administered in an inhalable form for the treatment of lower-respiratory tract infections such as pneumonia and tuberculosis. Other collaborators are testing the compound against a range of difficult to treat mycobacterial pathogens and assessing the toxicological properties.

• MSc projects

Publications

Goldberg, M (2019)  The Human Microbiome: The Extraordinary Biology of the Microbes that Live in and on Us , CPQ Microbiology (2019) 3:2,Editorial

Newell D.G, Manning, G., Goldberg, M., Morgan, D and Wassenaar, T.M. (2017) The Influence of Virulence Factors on Dose Response of Food-Borne Pathogens. In: Virulence Factors and Host Susceptibility in Foodborne Pathogens. Gurtler, J.B.,Doyle, M.P and Kornacki., J.L. (Eds.) Springer International Publishing

Chaudhuri R.R, Sebaihia M, Hobman J.L, Webber M.A, Leyton D.L, Goldberg M.D, Cunningham A.F, Scott-Tucker A, Ferguson P.R, Thomas C.M, Frankel G, Tang C.M, Dudley E.G, Roberts I.S, Rasko D.A, Pallen M.J, Parkhill J, Nataro J.P, Thomson N.R, Henderson I.R. (2010) Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042. PLoS One 5: e8801

Large, A.T., Goldberg, M.D. and Lund, P.A. (2008) Chaperones and protein folding in the Archaea. Biochem. Soc. Trans.37: 46-51.

Grainger, D.C. Goldberg, M.D., Lee, D.J. and Busby S.J.W. (2008) Selective repression by Fis and H-NS at the Escherichia coli dps promoter. Mol. Microbiol. 68: 1366-77.

Lucchini, S., Rowley, G., Goldberg, M. D., Hurd, D., Harrison, M. and Hinton, J. C. D. (2006) H-NS mediates the silencing of laterally acquired genes in bacteria. PLoS – Pathogens 2: 1-7

Grainger, D. C., Hurd, D., Goldberg, M. D. and Busby, S. J. W. (2006) Association of nucleoid proteins with coding and non-coding segments of the Escherichia coli genome. Nucleic Acids Res. 34: 4642-4652

Ono, S., Goldberg, M.D. Petrovic, A., Olsson, T., Eccleston, J.F., Hinton, J.C.D. and Ladbury, J.E. (2004) H-NS is a thermal switch for bacterial gene regulation in Salmonella enterica serovar Typhimurium. Biochem J. 391: 203-213

Kelly, A., Goldberg, M.D., Carroll, R.K., Danino, V., Hinton, J.C.D. and Dorman, C.J. (2004) A global role for Fis in the transcriptional control of metabolism and Type III secretion in Salmonella enterica serovar Typhimurium. Microbiology 150: 2037-2053

Goldberg M.D., Johnson, M., Hinton, J.C.D. and Williams, P.H. (2001) Role of the nucleoid-associated protein Fis in the regulation of virulence properties of enteropathogenic Escherichia coli. Mol Microbiol 41:  549-559.

Goldberg, M.D., Canvin, J.R. Freestone, P., Andersen, A., Laoudj, D., Williams, P.H. Holland, I.B. and Norris, V. (1997) Artefactual cleavage of E. coli H-NS by OmpT. Biochimie 79:  315-322.

Laoudj, D., Andersen, C.L., Brás, A., Goldberg, M., Jacq, A. and Holland, I.B. (1994) EGTA induces the synthesis in Escherichia coli of three proteins that cross-react with calmodulin antibodies. Mol Microbiol 13:  445-457.

Norris, V., Chen, M., Goldberg, M., Voskuil, J., McGurk, G. and Holland, I.B. (1991) Calcium in bacteria: a solution to which problem? (1991) Mol. Microbiol. 5: 775-778.

Casaregola, S., Chen, M., Bouquin, N., Norris, V., Jacq, A., Goldberg, M., Margarson, S., Tempete, M., McKenna, S., Sweetman, H., Bernard, S., McGurk, G., Seror, S. and Holland, I.B. (1991) Analysis of a myosin-like protein and the role of calcium in the Escherichia coli cell cycle. Res. Microbiol 142:  201-207.

Casaregola, S., Norris, V., Goldberg, M. and Holland, I.B. (1990) Identification of a 180kDa protein in Escherichia coli related to a yeast heavy-chain myosin. Mol. Microbiol 4:  505-511.

Invited presentations

Society for General Microbiology: Food-borne infections and intoxications. Leeds, UK. “Identification of the role of Fis in the regulation of virulence in enteropathogenic Escherichia coli”.

Instituto Tecnica de Quimica e Biologia, Lisbon, Portugal. Howcan a single protein regulate many unrelated genes? Surprising insights into the structure/function of H-NS in Salmonella enterica serovarTyphimurium.

Institute of Molecular Medicine, Lisbon, Portugal. Dissecting the 'brain' of Salmonella enterica serovar Typhimurium: towards an understanding of how H-NS regulates gene expression.

International E. coli Alliance, Hinxton, Cambridge, UK. Iron: a chink in the armour of enterohaemorrhagic Escherichia coli O157?

“Comparative genomics of pathogens” at 2nd Annual Food, Nutrition and Agriculture Genomics Congress, London.

Invited speaker at “Genome Research in Food Microbiology” meeting, Campden BRI, Chipping Campden, Gloucestershire

“Antibiotic Discovery Accelerator Network (ABX)” meeting

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